CCR1 Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CCR1 Antibody Summary

Immunogen
Synthetic peptide: TEDYDTTTEFDYGDATPC, corresponding to amino acids 7 - 24 of Human CCR1.
Epitope
N-terminal extracellular domain of human CCR1.
Localization
Cell Membrane
Specificity
Peptide sequence is < 50 % identical to other chemokine receptors in this region.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CCR1
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • ELISA 1:100000
  • Immunohistochemistry 1:200
Application Notes
In WB predicted molecular weight is 62. 6 kDa. Optimal dilutions/concentrations should be determined by the end user.
Positive Control
CCR1 Lysate (NBL1-08887)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
10 mM KHPO4, 140 mM NaCl, BSA
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR1 Antibody

  • C-C chemokine receptor type 1
  • CC-CKR-1
  • CCR1
  • CCR-1
  • CD191 antigen
  • CD191
  • chemokine (C-C motif) receptor 1
  • CKR1
  • CKR-1
  • CMKBR1SCYAR1
  • CMKR1
  • HM145C-C CKR-1
  • LD78 receptor
  • Macrophage inflammatory protein 1-alpha receptor
  • MIP-1alpha-R
  • MIP1aR
  • RANTES receptor
  • RANTES-R

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu
Applications: WB, ELISA, IHC

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for CCR1 Antibody (NB100-719). (Showing 1 - 1 of 1 FAQ).

  1. What is the concentration of sodium azide for cat# NB100-719?
    • The CCR1 antibody with catalog number NB100-719 is supplied in PBS pH7.2 with 1mg/ml BSA and 0.1 % sodium azide.

Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for CCR1 Antibody (NB100-719)

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Blogs on CCR1.

CCR1 (C-C chemokine receptor type 1)
Chemokines play a central role in inflammation and are crucial for recruitment of immune cells to sites of infection. The chemokine-dependent activation of leukocytes occurs through binding to G-protein coupled receptors. These chemokine receptor s...  Read full blog post.

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Bioinformatics

Gene Symbol CCR1
Entrez