CCL5/RANTES Antibody Pair [HRP]

ELISA: CCL5/RANTES Antibody Pair [HRP] [NBP3-11652] - Sample standard curve

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP
• Standard Curve Range: 0.78-50 pg/ml (example only; lot dependent)
• Sensitivity: 0.78 pg/mll (example only; lot dependent)

CCL5/RANTES Antibody Pair [HRP] Summary

• Description: This Human CCL5/RANTES Antibody Pair [HRP] is a solid phase sandwich ELISA for quantitative determination of Human CCL5/RANTES
• Specificity: This solid phase sandwich ELISA utilizes a monoclonal antibody specific for Human CCL5/RANTES.
• Standard Curve Range: 0.78-50 pg/ml (example only; lot dependent)
• Sensitivity: 0.78 pg/mll (example only; lot dependent)
• Assay Type: Sandwich ELISA
• Sample Volume: 100 ul
• Gene: CCL5

Applications/Dilutions

• Dilutions:
  • ELISA
  • Sandwich ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for CCL5/RANTES Antibody Pair [HRP]

• CCL5
• chemokine (C-C motif) ligand 5
• D17S136Enormally T-expressed, and presumably secreted
• EoCP
• Eosinophil chemotactic cytokine
• RANTES
• RANTES/CCL5
• SISd
• SIS-delta
• small inducible cytokine A5 (RANTES)
• small inducible cytokine subfamily A (Cys-Cys), member 5
• Small-inducible cytokine A5
• T cell-specific protein P228
• T-cell specific protein p288
• TCP228T-cell-specific protein RANTES

Background

RANTES (Regulated-on-activation-normal-T-cell-expressed-and-secreted) is a member of the "intercrine/chemokine" family of cytokines, has been previously shown to be chemotactic for monocytes and T cells of memory/helper phenotype. RANTES has been shown to cause the release of histamine from basophils and activates eosinophils. It also binds to CCR1, CCR3, CCR4 and CCR5 (1). This CC-chemokine enhances antigen-specific T helper (Th) type-1 responses against HIV-1 (2). CC chemokines are small inducible proteins that are related to interleukin 8. In lung adenocarcinoma, RANTES is a predictor of survival while that of interleukin (IL)-8 is associated with a poor prognosis. In several models, tumorigenesis is abolished by RANTES, while it is facilitated by IL-8. Site-directed mutagenesis indicated that regulation of RANTES promoter activity required two nuclear factor (NF)-kappaB response elements but not its activator protein (AP)-1 binding sites (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: CCL5