CCL5/RANTES Products

Description

RANTES (Regulated-on-activation-normal-T-cell-expressed-and-secreted) is a member of the "intercrine/chemokine" family of cytokines, has been previously shown to be chemotactic for monocytes and T cells of memory/helper phenotype. RANTES has been shown to cause the release of histamine from basophils and activates eosinophils. It also binds to CCR1, CCR3, CCR4 and CCR5 (1). This CC-chemokine enhances antigen-specific T helper (Th) type-1 responses against HIV-1 (2). CC chemokines are small inducible proteins that are related to interleukin 8. In lung adenocarcinoma, RANTES is a predictor of survival while that of interleukin (IL)-8 is associated with a poor prognosis. In several models, tumorigenesis is abolished by RANTES, while it is facilitated by IL-8. Site-directed mutagenesis indicated that regulation of RANTES promoter activity required two nuclear factor (NF)-kappaB response elements but not its activator protein (AP)-1 binding sites (3).

Bioinformatics

Entrez	20304 Mouse 6352 Human 81780 Rat
Uniprot	AAH08600 Human NM_002985 Human NM_002985.2 Human NP_002976 Human P13501 Human P30882 Mouse
Product By Gene ID	6352
Alternate Names	chemokine (C-C motif) ligand 5 D17S136Enormally T-expressed, and presumably secreted EoCP Eosinophil chemotactic cytokine SIS-delta small inducible cytokine A5 (RANTES) small inducible cytokine subfamily A (Cys-Cys), member 5 Small-inducible cytokine A5 T cell-specific protein P228 T-cell specific protein p288 TCP228T-cell-specific protein RANTES

Research Areas for CCL5/RANTES

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cytokine Research
Immunology
Innate Immunity