Caveolin-1 Antibody

Western Blot: Caveolin-1 Antibody [NB300-509] - Analysis of rat heart protein extract.

• Reactivity: Hu, Mu, Rt, Ca, Ha
• Applications: WB, Flow, ICC/IF, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

Caveolin-1 Antibody Summary

• Description: Novus Biologicals Rabbit Caveolin-1 Antibody (NB300-509) is a polyclonal antibody validated for use in IHC, WB, Flow, ICC/IF and IP. Anti-Caveolin-1 Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide corresponding to residues M(1) S G G K Y V D S E G H L Y T V P(17) C of human CAV1.
• Marker: Caveolae Marker, Endosome Marker
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CAV1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 3 - 5 ug / 10^6 cells
  • Immunocytochemistry/ Immunofluorescence 1 - 2 ug/ml
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 5 ug
  • Western Blot 1 - 2 ug/ml
• Application Notes: IHC usage was reported in scientific literature (PMID: 11257005).
• Control:

  Caveolin-1 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Caveolin-1 Antibody

• CAV
• CAV1
• caveolae protein, 22kD
• caveolin 1, caveolae protein, 22kDa
• Caveolin1
• Caveolin-1
• cell growth-inhibiting protein 32
• MSTP085
• VIP21

Background

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Caveolin-1 Antibody (NB300-509)(4)

Publications using NB300-509

• Jimenez M, Lasso P, Fiorentino S et al. Petiveria alliacea and Caesalpinia spinosa extracts reduce the generation of cancer-associated fibroblasts in a 3D platform representative of the tumor microenvironment. Cancer Cell International 2025-07-02 [PMID: 40605001]
• Jim�nez M, Prieto K, Lasso P et al. Plant extract from Caesalpinia spinosa inhibits cancer-associated fibroblast-like cells generation and function in a tumor microenvironment model Heliyon 2023-03-01 [PMID: 36923867] (ICC/IF, WB)
• Martin GG, Danneberg H, Kumar LS et al. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. J Biol Chem. 2003-06-01 [PMID: 12670956]
• Li WP, Liu P, Pilcher BK et al. Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria. J Cell Sci. 2001-04-01 [PMID: 11257005]

Bioinformatics

• Gene Symbol: CAV1
• Entrez:
  • 857(Human)
  • 12389(Mouse)
  • 25404(Rat)
• Uniprot:
  • Q03135()