BRD8 Antibody

Images

 
Western Blot: BRD8 Antibody [NB100-79781] - Detection of Human BRD8 by Western Blot. Samples: Nuclear extract (50 ug) from HeLa and 293T cells. Antibodies: Affinity purified rabbit anti-BRD8 antibody NB100-79781 used ...read more
Immunohistochemistry: BRD8 Antibody [NB100-79781] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-BRD8 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB staining using ...read more
Western Blot: BRD8 Antibody [NB100-79781] - A) Nuclear extract (NE; 5, 15 and 50 mcg) from HeLa cells. B) Nuclear extract (1 mg) from HeLa cells. Antibodies: A) Rabbit anti-BRD8 antibody, NB100-79781 used at the ...read more
Immunohistochemistry-Paraffin: BRD8 Antibody [NB100-79781] - FFPE section of human prostate adenocarcinoma. Affinity purified rabbit anti-BRD8 used at a dilution of 1:100.
Immunohistochemistry-Paraffin: BRD8 Antibody [NB100-79781] - Human prostate carcinoma. Antibody used at a dilution of 1:1000 (1ug/ml).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

BRD8 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 200 and 250 of human Bromodomain containing 8 using the numbering given in TrEMBL entry Q969M9 (GeneID 10902).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BRD8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:10000-1:25000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 2-8 ug/mg lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for BRD8 Antibody

  • bromodomain containing 8
  • bromodomain-containing protein 8
  • Skeletal muscle abundant protein
  • SMAP2
  • SMAPp120Skeletal muscle abundant protein 2
  • Thyroid hormone receptor coactivating protein of 120 kDa
  • trCP120

Background

BRD8 may act as a coactivator during transcriptional activation by hormone activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, IHC, IHC-P, IP

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol BRD8
Entrez
Uniprot