BP1 Antibody [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

BP1 Antibody [DyLight 405] Summary

Immunogen
A synthetic peptide made specifically to the human BP1 protein sequence (between residues 1-60) [UniProt# Q92988].
Localization
Nuclear.
Specificity
This is specific for human BP1 (DLX4 variant 1). Berg PE, Kirolikar S. DLX4 (distal-less homeobox 4). Atlas Genet Cytogenet Oncol Haematol. January 2011. URL : http://AtlasGeneticsOncology.org/Genes/DLX4ID49827ch17q21.html
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DLX4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This BP1 antibody is useful for Immunohistochemistry on paraffin-embedded sections, Immunoprecipitation and Western blot, where a band is seen at ~36 kDa. IP has been done with 35S-labeled BP1 protein only. It is not known if this antibody will immunoprecipitate a cell extract.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Immunogen sequence has 82% homology with mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for BP1 Antibody [DyLight 405]

  • Beta protein 1
  • BP1distal-less homeo box 7
  • distal-less homeobox 4
  • DLX7distal-less homeo box 9
  • DLX8DLX9
  • homeobox protein DLX-4
  • Homeobox protein DLX-7
  • Homeobox protein DLX-8

Background

BP1 (beta protein 1; also called distal-less homeobox gene 4 or DLX4) is a member of DLX family of homeobox genes and it controls many aspects of embryonic development including bone morphogenesis, skeletal patterning and cell differentiation. Originally discovered to be a repressor of beta-globin gene in erythroid cells, BP1 is normally expressed during early hematopoiesis with complete absence from most normal adult tissues and is widely re-expressed in leukemias, lung, breast, ovarian as well as prostate cancers. BP1 is an oncogene with a major role in breast cancer, and that its expression correlates with breast cancer progression and invasion. BP1 has been found to be detectable in 80% of infiltrating ductal carcinomas, but undetectable in matched normal controls, being the first DLX gene to be strongly implicated in breast cancer. Furthermore, expression of DLX4 correlates with estrogen receptor status and also cancer progression and invasion in breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for BP1 Antibody (NB100-481V)

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Research Areas for BP1 Antibody (NB100-481V)

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Blogs on BP1.

BRCA1 - A Critical Tumor Suppressor Gene in Women
Breast cancer 1, early onset (BRCA1) is a well-known tumor suppressor gene that was originally discovered due to its link with early-onset breast and ovarian cancer in women. The BRCA1 protein contains the following domains: RING finger, RAD51-interac...  Read full blog post.

BP1 Antibodies, Beta Globin and Breast Cancer: Today's post is brought to you by the letter 'B'
The transcription factor beta protein 1 (BP1) is a member of the homeobox gene family and the distal-less subfamily. Expression of BP1 is highly tissue-specific and developmentally restricted. Among different human tissues, BP1 is found to be highly e...  Read full blog post.

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Bioinformatics

Gene Symbol DLX4