BMP-7 Antibody (164324) [Biotin]

• Reactivity: Hu
• Applications: ELISA(Det)
• Clone: 164324
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin
• Concentration: LYOPH

BMP-7 Antibody (164324) [Biotin] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human BMP‑7
  Arg292-His431
  Accession # P18075
• Specificity: Detects human BMP-7 in ELISAs. In ELISAs, this antibody shows less than 0.125% cross-reactivity with recombinant human (rh) BMP-2, rhBMP-3, rhBMP-4, rhBMP-5, rhBMP-6, rhBMP-8, rhTGF-beta 1, rhTGF-beta 2, or rhTGF-beta 3.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: BMP7
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • ELISA Standard (Matched Pair)
• Application Notes: ELISA Capture: Human BMP-7 Antibody (Catalog # MAB3542) ELISA Detection: Human BMP-7 Biotinylated Antibody (Catalog # BAM354) Standard: Recombinant Human BMP-7 (Catalog # 354-BP)
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMP-7 Antibody (164324) [Biotin]

• BMP7
• BMP-7
• bone morphogenetic protein 7
• Eptotermin alfa
• OP-1
• OP-1OP1
• Osteogenic protein 1

Background

BMP-7, also known as Osteogenic Protein 1 (OP-1), is one of at least 15 structurally and functionally related BMPs, which are members of the TGF-beta superfamily. BMPs regulate cartilage and bone formation, embryogenesis and morphogenesis of various tissues and organs, and growth, differentiation, chemotaxis, and apoptosis of various cell types. Biologically active BMP-7 is a disulfide-linked homodimer. Cellular responses to BMP-7 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BMP-7 Antibody (BAM354)(1)

Publication using BAM354

• R Oude Egber, HM Zegelaar, N El Boujnou, EMM Versteeg, WF Daamen, R Brock Biomaterial-Mediated Protein Expression Induced by Peptide-mRNA Nanoparticles Embedded in Lyophilized Collagen Scaffolds Pharmaceutics, 2022-08-02;14(8):. 2022-08-02 [PMID: 36015245] (ELISA Detection, Mouse)

Bioinformatics

• Gene Symbol: BMP7
• Uniprot:
  • P18075()