ATP7b Antibody [PE]

• Reactivity: Hu, Rt, Mu(-)
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: PE

ATP7b Antibody [PE] Summary

• Immunogen: A synthetic peptide made to an internal sequence near the C-terminus of human ATP7b. [UniProt# P35670]
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ATP7B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Does not appear to react in mouse species.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ATP7b Antibody [PE]

• ATPase, Cu(2+)- transporting, beta polypeptide
• ATPase, Cu++ transporting, beta polypeptide
• Copper pump 2
• copper-transporting ATPase 2
• EC 3.6.3
• EC 3.6.3.4
• PWD
• WC1
• WD
• Wilson disease-associated protein
• WNDATPase, Cu++ transporting, beta polypeptide (Wilson disease)

Background

ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; form A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ATP7B