Synthetic peptides corresponding to FBXW7(F-box and WD repeat domain containing 7) The peptide sequence was selected from the C terminal of FBXW7 (NP_001013433). Peptide sequence LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVL. The peptide sequence for this immunogen was taken from within the described region.
Predicted Species
Rat (100%), Canine (100%), Equine (100%), Rabbit (100%), Guinea Pig (100%), Bovine (100%), Zebrafish (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FBXW7
Purity
Immunogen affinity purified
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This is a rabbit polyclonal antibody against FBXW7 and was validated on Western blot.
Theoretical MW
66 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Mouse reactivity reported in scientific literature (PMID: 25822340).
Packaging, Storage & Formulations
Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified
Notes
The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
Alternate Names for FBXW7/Cdc4 Antibody
AGO
AGOFBXO30
Archipelago Homolog
archipelago, Drosophila, homolog of
Cdc4
CDC4FLJ16457
F-box and WD repeat domain containing 7
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
F-box and WD-40 domain-containing protein 7
F-box protein FBW7
F-box protein FBX30
F-box protein SEL-10
F-box/WD repeat-containing protein 7
FBW6
Fbw7
FBW7hCdc4
FBX30
FBX30FLJ11071
FBXO30
FBXW6
FBXW7
hAgo
homolog of C elegans sel-10
SCF(Fbw7)
SEL10
SEL-10DKFZp686F23254
SEL10FBW6
Background
FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Bioinformatics Tool for FBXW7/Cdc4 Antibody (NBP1-59631)
Discover related pathways, diseases and genes to FBXW7/Cdc4 Antibody (NBP1-59631). Need help?
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Diseases for FBXW7/Cdc4 Antibody (NBP1-59631)
Discover more about diseases related to FBXW7/Cdc4 Antibody (NBP1-59631).
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