APAF-1 Antibody (94408) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 94408
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

APAF-1 Antibody (94408) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human APAF-1
  Leu10-Asp214
  Accession # AAC51678
• Specificity: Detects human APAF-1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for APAF-1 Antibody (94408) [Alexa Fluor® 647]

• APAF1
• APAF-1
• APAF-1apoptotic protease activating factor 1
• apoptotic peptidase activating factor 1
• apoptotic peptidase activating factor
• apoptotic protease activating factor
• apoptotic protease-activating factor 1
• CED4
• DKFZp781B1145
• KIAA0413

Background

Apoptosis protease-activating factor 1 (APAF‑1) is a ubiquitous 135 kDa protein component of the cytoplasmic apoptosome complex. APAF‑1 plays an important role in the mitochondrial apoptotic pathway by triggering the Cytochrome c-dependent activation of Caspase-9. APAF‑1 participates in tissue morphogenesis during development, and loss of APAF‑1 expression is associated with tumor progression in a variety of cancers. Some alternate splice forms of APAF‑1 are deficient in their ability to promote apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.