APAF-1 Products

Antibodies
APAF-1 Antibody
APAF-1 Antibody
NB100-56074
Species: Hu, Mu, Rt, Ge
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
APAF-1 Antibody (94408)
APAF-1 Antibody (94408)
MAB868
Species: Hu
Applications: WB
Host: Mouse Monoclonal
APAF-1 Antibody
APAF-1 Antibody
NBP1-77000
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
APAF-1 Overexpression Lysate ...
APAF-1 Overexpression Lysate (Dena...
H00000317-T01
Species: Hu
Applications: WB
APAF-1 Overexpression Lysate ...
APAF-1 Overexpression Lysate (Native)
NBP2-04870
Applications: WB
Proteins
APAF-1 Partial Recombinant Pr ...
APAF-1 Partial Recombinant Protein
H00000317-Q01
Species: Hu
Applications: WB, ELISA, PA
APAF-1 Recombinant Protein An ...
APAF-1 Recombinant Protein Antigen
NBP1-89050PEP
Species: Hu
Applications: AC
APAF-1 Peptide
APAF-1 Peptide
NBP1-76999PEP
Species: Hu
Applications: AC
RNAi
APAF-1 RNAi
APAF-1 RNAi
H00000317-R01
Species: Hu
APAF-1 RNAi
APAF-1 RNAi
H00000317-R04
Species: Hu
APAF-1 RNAi
APAF-1 RNAi
H00000317-R03
Species: Hu

Description

Apaf 1 (apoptosis protease-activating factor-1) is a key regulator of the mitochondrial apoptotic pathway (reviewed in Campioni et al, 2005), being the central element of the multimeric apoptosome. The apoptosome consists of cytochrome c, procaspase-9 and seven Apaf 1 monomers, and is considered to be core apoptotic machinery that executes mitochondria-dependent apoptosis. Cytochrome c, normally compartmentalized in the mitochorndria, is released into the cytoplasm following apoptotic stimuli. Apaf 1 binds cytochrome c in the cytoplasm and in the presence of dATP/ATP forms the apoptosome. The apoptosome binds procaspase-9 and promotes its autocatalytic activation. Active caspase-9, in turn, activates downstream caspases including 3, 6, and 7 contributing to the proteolytic caspase activation cascade which leads to cell death. Apaf 1 is an approx. 130 kDa protein. Alternative Apaf 1 splicing isoforms of Apaf 1 have been identified in mammalian cells, each having either or both an 11 amino acid insertion in the N-terminus and an additional WD40 repeat (43 aa) in the C-terminus; please refer to AceView of NCBI (http://www.ncbi.nih.gov/IEB/Research/Acembly/) for detailed information. Additionally, Apaf 1 can be proteolytically processed by active caspase-3 during apoptosis resulting in an Apaf 1 cleavage fragment of ~84 kDa (Lauber et al. 2001).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 317
Alternate Names
  • apoptotic protease activating factor
  • KIAA0413
  • apoptotic peptidase activating factor
  • apoptotic protease-activating factor 1
  • CED4
  • APAF-1apoptotic protease activating factor 1
  • DKFZp781B1145
  • apoptotic peptidase activating factor 1

Research Areas for APAF-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Mitochondrial Markers
Tumor Suppressors

Bioinformatics Tool for APAF-1

Discover related pathways, diseases and genes to APAF-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related APAF-1 Blog Posts

Check out the latest blog posts on APAF-1.
Caspase 9 - an important apoptosis marker
Caspases are essential mediators of programmed cell death and are needed for both the induction of apoptosis as well as for aiding the degradation of cellular structures. Initiator caspases (such as Caspase-9) sense and respond to various signals i...    Read more.
Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...    Read more.
The Role of the Caspase 3 Antibody in Apoptosis Research
The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.Human caspases form three distinct groups: cytokine activators, which are...    Read more.
Read more APAF-1 related blogs.