APAF-1 Products

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1 (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 transcript is ubiquitously expressed in human tissues (1).

Bioinformatics

Entrez	317 Human 78963 Rat
Product By Gene ID	317
Alternate Names	APAF1 APAF-1 APAF-1apoptotic protease activating factor 1 apoptotic peptidase activating factor 1 apoptotic peptidase activating factor apoptotic protease activating factor apoptotic protease-activating factor 1 CED4 DKFZp781B1145 KIAA0413

Research Areas for APAF-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Mitochondrial Markers
Tumor Suppressors

Related APAF-1 Blog Posts

Check out the latest blog posts on APAF-1.

Caspase 9 - an important apoptosis marker Caspases are essential mediators of programmed cell death and are needed for both the induction of apoptosis as well as for aiding the degradation of cellular structures. Initiator caspases (such as Caspase-9) sense and respond to various signals i...    Read more.

Heat Shock Proteins: An Overview Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...    Read more.

The Role of the Caspase 3 Antibody in Apoptosis Research The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.Human caspases form three distinct groups: cytokine activators, which are...    Read more.

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