Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 370207
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Alexa Fluor® 750] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Angiopoietin-like 3
  Ser17-Glu460
  Accession # Q9Y5C1
• Specificity: Detects human ANGPTL3 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows approximately 40% cross‑reactivity with recombinant mouse (rm) ANGPTL3 and no cross-reactivity with rhAng-1, rhAng-2, or rhAng-4.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Alexa Fluor® 750]

• AGNPT5
• Ang-5
• angiopoietin 5
• Angiopoietin-5
• angiopoietin-like 3
• Angiopoietin-like Protein 3
• angiopoietin-related protein 3
• ANGPT5angiopoietin-5
• ANGPTL3
• FHBL2

Background

Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that belongs to the angiopoietin family. It is expressed in the liver and circulates as 70 kDa, 50 kDa, and 32 kDa species. These include full length ANGPTL3 as well as the proteolytically separated N- and C-terminal fragments which contain a coiled coil domain and fibrinogen-like domain, respectively. ANGPTL3 promotes an increase in circulating triglyceride levels by directly inhibiting lipoprotein lipase. Mature human ANGPTL3 shares 77% amino acid sequence identity with mouse ANGPTL3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.