Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB
• Clone: 370207
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Janelia Fluor® 669] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Angiopoietin-like 3
  Ser17-Glu460
  Accession # Q9Y5C1
• Specificity: Detects human ANGPTL3 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows approximately 40% cross‑reactivity with recombinant mouse (rm) ANGPTL3 and no cross-reactivity with rhAng-1, rhAng-2, or rhAng-4.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: ANGPTL3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Angiopoietin-like Protein 3/ANGPTL3 Antibody (370207) [Janelia Fluor® 669]

• AGNPT5
• Ang-5
• angiopoietin 5
• Angiopoietin-5
• angiopoietin-like 3
• Angiopoietin-like Protein 3
• angiopoietin-related protein 3
• ANGPT5angiopoietin-5
• ANGPTL3
• FHBL2

Background

ANGPTL3 is a 460 amino acid protein that is found most commonly in the liver, but has also been shown to reside in kidney samples, and contains three domains consisting of a signal peptide, N-terminal coiled-coil and C-terminal Fibrinogen (FBN) like domain. This protein is involved with the lipid metabolism disease pathways in relation to low levels of LDL (low density lipoproteins), HDL (High density lipoproteins), and triglycerides in plasma. This protein plays a role in angiogenesis and has been shown to interact with ITGAV, ITGB3, and ITGA5, and work is being done to study the protein and the related hypobetalipoproteinemia and atherosclerosis involvement.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ANGPTL3