LNCaP human prostate cancer cell line was stained with Mouse Anti-Human/Mouse/Rat Androgen R/NR3C4 Monoclonal Antibody (Catalog # MAB5876, filled histogram) or isotype control antibody (Catalog # MAB0041, open ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Androgen R/NR3C4 Antibody (523339) [Unconjugated]
Nuclear receptor subfamily 3 group C member 4
spinal and bulbar muscular atrophy
ligand binding domain of human AR (aa 661-920) shares 100% aa sequence
identity with mouse and rat AR. AR (Androgen receptor) is a 99 kDa
(predicted) member of the NR3 subfamily, nuclear hormone receptor family
of proteins. Due to a high number of Gln and Pro residues, it runs
anomalously at 100‑120 kDa in SDS-PAGE. It is widely expressed, being
found in neurons, endothelial cells, osteoblasts, chrondrocytes,
mascrophages, adipocytes, and prostate epithelium. Human AR is 919 amino
acids (aa) in length. It contains three discrete domains: a
"modulating" N‑terminus (aa 1‑553) that is rich in Gln, Pro and Gly, a
Zn-finger DNA-binding region (aa 554‑635), and a ligand-binding domain
(aa 672‑917). AR is highly polymorphic at the N‑terminus, with total Gln
and Gly residues differing by seven or more residues among individuals.
Multiple potential splice forms exist, including an alternative start
site at Met189 and a seven aa substitution for aa 1‑538 that generates a
45 kDa isoform. AR does homodimerize, apparently with multiple
isotypes. Over aa 661‑920, human and mouse are identical in aa sequence.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
Review this Product
Be the first to review our Androgen R/NR3C4 Antibody (523339) [Unconjugated] and receive a gift card or discount.