Immunocytochemistry/ Immunofluorescence: ABCB5 Antibody [NBP1-77687] - ABCB5 antibody was tested in A431 cells with FITC (green). Nuclei and actin were counterstained with DAPI (blue) and Phalloidin (red).
Immunohistochemistry: ABCB5 Antibody [NBP1-77687] - Analysis of ABCB5 in mouse spleen using DAB with hematoxylin counterstain.
This ABCB5 antibody is useful for Immunocytochemistry/Immunofluorescence and IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Use in Western blot reported in scientific literature (PMID: 25030174).
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for ABCB5 Antibody
ATP-binding cassette protein
ATP-binding cassette sub-family B member 5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
The ATP-binding cassette sub-family B member 5 (ABCB5) is an ABC transporter and PGP member. It is highly expressed in skin and in malignant melanoma. When two abnormal growths of tissues occur, resulting in multiple malignancies, ABCB5 is often highly expressed. This elevated expression in tumor cells can indicate a propensity towards therapeutic failure in many cases. Analysis of ABCB5 concentrations in tumors has been suggested as a fairly dependable qualitative biomarker for assessing the malignancy of melanomas.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.