ABCA7 Antibody (7A1-144) [Alexa Fluor™ Plus 488]

• Reactivity: Mu
• Applications: WB, Flow, IHC
• Clone: 7A1-144
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 488

ABCA7 Antibody (7A1-144) [Alexa Fluor™ Plus 488] Summary

• Immunogen: Mouse ABCA7 stably-transfected HeLa cells. [UniProt# Q91V24]
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Rat
• Gene: ABCA7
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ABCA7 Antibody (7A1-144) [Alexa Fluor™ Plus 488]

• ABCA-SSN
• ABCXATP-binding cassette sub-family A member 7
• ATP-binding cassette, sub-family A (ABC1), member 7
• Autoantigen SS-N
• EC 2.2.1.1
• EC 3.6.3
• EC 3.6.3.41
• FLJ40025
• Macrophage ABC transporter

Background

ATP-binding cassette sub-family A member 7 (ABCA7), is a member of the ATP-binding cassette sub-family A. ABCA7 is thought to have a role in phagocytosis apoptotic cells macrophages.

ABCA-7 is highly homologous to ABCA1, and also mediates cellular cholesterol and phospholipid release by apolipoproteins. The ABCA7 gene is regulated by sterol in the opposite direction to ABCA1 through SRE/SREBP2. The expression of ABCA7 by this regulation is associated with phagocytic activity. As well, it binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. It also may mediate cholesterol efflux.

ABCA7 antibodies are useful for studies of cholesterol formation and lipid processing mechanisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCA7