5-HT6 Antibody

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Immunohistochemistry-Paraffin: 5-HT6 Antibody [NLS652] - Analysis of anti-5HT6 antibody with human brain, cerebellum.

Product Details

Summary
Reactivity Hu, Rt, Ca, Eq, Ha, Mk, Pm, Mu, Bt, Bv, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.7 mg/ml

Order Details

5-HT6 Antibody Summary

Immunogen
Synthetic 17 amino acid peptide from C-terminus of human HTR6 / 5-HT36.
Localization
Multi pass membrane protein.
Specificity
Human HTR6 / 5-HT36. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (94%), Bovine (94%), Rabbit (94%), Bat (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HTR6
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 10 - 20 ug/ml
Positive Control
5-HT6 Lysate (NBL1-11782)

Reactivity Notes

Chimpanzee, Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Elephant (94%), Stickleback (88%), Pufferfish (88%), Turkey (82%), Chicken (82%), Xenopus (82%), Zebrafish (82%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
0.7 mg/ml
Purity
Immunogen affinity purified

Alternate Names for 5-HT6 Antibody

  • 5-HT6
  • 5-hydroxytryptamine (serotonin) receptor 6,5-HT65-HT6R
  • HTR6
  • Serotonin receptor 6,5-HT-6,5-hydroxytryptamine receptor 6

Background

5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. 5-HT6 Receptor has been reported primarily in striatum of the brain. Expression has also been seen in stomach, spinal cord, and the lymphoid tissues of rats, including peripheral blood lymphocytes, spleen, and thymus. ESTs have been isolated from brain libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HTR6
Entrez
Uniprot