Animal Models to Study Autophagy

Autophagy and Apoptosis: who regulates whom?

Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences

Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation of autophagy and oncogenic suppression (1). He et al 2013 documented that human Beclin 2 is 57% similar to Beclin 1, and they confirmed its presence in several tissues including brain, placenta, thymus, uterus and skeletal muscles.