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Mitophagy

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
HIV
Human Immunodeficiency Virus
Mitochondria
Mitophagy
ROS
Oxidative Stress
GP120
Tat
Methamphetamine
neurodegeneration
Neurons
LC3B
p62
Autophagy
MAP2
DRP1
Antioxidants
Jamshed Arslan

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles

Expression of the mitochondrial fission protein DRP1 in NH3T3 cells was analyzed by immunocytochemistry with knockout validated rabbit polyclonal anti-DRP1 antibody.

By Christina Towers, PhD

Tags: 
Autophagy
Selective Autophagy
Mitophagy
PINK1
p62/SQSTM1
NBR1
NDP52
OPTN
TAX1BP1
Parkin
DRP1
Christina Towers

New Players in the Mitophagy Game

Adenine nucleotide translocase 1 or ADP/ATP translocase (ANT) is expressed in the inner mitochondrial membrane where it exchanges free ATP and ADP from and into the mitochondrial matrix, respectively.

By Christina Towers, PhD

Tags: 
Autophagy
Selective Autophagy
Mitophagy
SYNJ2BP/ARIP2
cox8a
PINK1
Adenine nucleotide translocase 1
timm44
timm23
Parkin
Christina Towers

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch

sAmbra1 expression and localization to mitochondria in human U-2 OS cell line, ICC

By Christina Towers, PhD

Tags: 
Autophagy
Mitophagy
LC3
LC3-II
LC3B
p62/SQSTM1
Parkin
AMBRA1
Christina Towers

How to visualize autophagy by microscopy

LC3B and alpha tubulin expression in HeLa cells treated with Chloroquine, ICC, immunocytochemistry, immunofluorescence

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
p62/SQSTM1
alpha Tubulin
GFP
Mitophagy
mCherry
Autophagic flux
Chloroquine
Christina Towers
Autophagy flux
microscopy

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease

Map2 and Fox3/NeuN expression in rat hippocampus, IHC

 

By Jamshed Arslan Pharm.D.

 

Tags: 
Neuroscience
neurodegeneration
Alzheimer's
Autophagy
Mitophagy
APP
amyloid beta
DRP1
Fis1/ttc11
OPA1
Mfn1
Mfn2
Pgc1-alpha
NRF1
NRF2
TFAM/mtTFA
PSD-95
Synaptophysin
MAP2
ATG5
beclin-1
LC3A
LC3B
PINK1
TERT
Bcl-2
Bnip3l
Jamshed Arslan
Western blot
Immunoblot
mAPP
Immunofluorescence

Crosstalk Between Oxidative Stress and Autophagy

Autophagosome and lysosome fusion, following macroautophagy to sequester cytosolic components within the autophagosome, forms autolysosome

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3B
p62/SQSTM1
Keap1
NRF2
Glutathione Peroxidase
SOD
Western blot
ROS
RNS
redoxstasis
Gpx
Oxidative Stress
Mitophagy
Christina Towers

There's an autophagy for that!

By Christina Towers, PhD

Tags: 
Autophagy
PINK1
Parkin
Ubiquitin
p62
Parkinson
Mitochondria
Mitophagy