ZC3HAV1L Antibody

Images

 
Western Blot: ZC3HAV1L Antibody [NBP1-77184] - HeLa cell lysate with ZC3HAV1 antibody at 1ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: ZC3HAV1L Antibody [NBP1-77184] - ZC3HAV1 in Hela cells with ZC3HAV1 antibody at 20 ug/mL.
Immunocytochemistry/ Immunofluorescence: ZC3HAV1L Antibody [NBP1-77184] - HeLa cells with ZC3HAV1 antibody at 20 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ZC3HAV1L Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human ZC3HAV1. The immunogen is located within amino acids 680 - 730 of ZC3HAV1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ZC3HAV1L
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
ZC3HAV1 antibody can be used for detection of ZC3HAV1 by Western blot at 0.5 - 1 mg/ml.
Control Peptide
ZC3HAV1L Peptide (NBP1-77184PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ZC3HAV1L Antibody

  • C7orf39
  • chromosome 7 open reading frame 39
  • MGC14289
  • zinc finger CCCH-type antiviral protein 1-like
  • zinc finger CCCH-type, antiviral 1-like

Background

The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ZC3HAV1L
Uniprot