WNK4 Antibody - BSA Free

Immunohistochemistry: WNK4 Antibody [NBP1-92597] - Staining of human kidney shows strong cytoplasmic and nuclear positivity in cells in tubules.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

WNK4 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit WNK4 Antibody - BSA Free (NBP1-92597) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: ISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAEL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: WNK4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  WNK4 Protein (NBP1-92597PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (87%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for WNK4 Antibody - BSA Free

• EC 2.7.11
• EC 2.7.11.1
• PHA2B
• PRKWNK4protein kinase, lysine deficient 4
• Protein kinase lysine-deficient 4
• Protein kinase with no lysine 4
• serine/threonine-protein kinase WNK4
• WNK lysine deficient protein kinase 4

Background

WNK lysine deficient protein kinase 4 (WNK4) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. The role of WNK4 in kidney physiology is to act as a molecular switch between NaCl reabsorption (volume retention) and K+ secretion (waste release).

WNK4 mutations have been associated with an autosomal dominant disease called pseudohypoaldosteronism type II.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: WNK4