VEGFR2/KDR/Flk-1 Antibody (EIC) [PerCP]

Product Discontinued

VEGFR2/KDR/Flk-1 Antibody (EIC) [PerCP] Summary

• Immunogen: Recombinant human soluble extracellular KDR (D7)
• Localization: Type I membrane protein.
• Marker: Endothelial Cell Marker
• Specificity: The monoclonal will detect native human VEGFR-2 / KDR in ELISA experiments and on the surface of different human cell types.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KDR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 20837901).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for VEGFR2/KDR/Flk-1 Antibody (EIC) [PerCP]

• CD309 antigen
• CD309
• EC 2.7.10
• EC 2.7.10.1
• Fetal liver kinase 1
• fetal liver kinase-1
• Flk1
• Flk-1
• FLK1tyrosine kinase growth factor receptor
• KDR
• kinase insert domain receptor (a type III receptor tyrosine kinase)
• Kinase insert domain receptor
• KRD1
• Ly73
• Protein-tyrosine kinase receptor flk-1
• soluble VEGFR2
• vascular endothelial growth factor receptor 2
• VEGF R2
• VEGFR
• VEGFR2
• VEGFR-2

Background

Vascular endothelial growth factor receptor 2 (VEGFR2) is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other common growth factor receptors, VEGF receptor 2 dimerises upon ligand binding and is autophosphorylated at multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or can serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Defects in the VEGFR2 gene are associated with susceptibility to benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium called hemangioma capillary infantile. HCI is the most common tumor found in infants, found in up to 10% of all births.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for VEGFR2/KDR/Flk-1 Antibody (NB200-208PCP) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Rat.

reviewed by: Verified Customer Flow Rat 06/21/2016

Summary

• Application: Flow Cytometry
• Sample Tested: PBMC
• Species: Rat

Bioinformatics

• Gene Symbol: KDR
• Entrez:
  • 3791(Human)
  • 25589(Rat)