VCAM-1/CD106 Antibody (AP-MAB0829)

Product Discontinued

VCAM-1/CD106 Antibody (AP-MAB0829) Summary

• Immunogen: Mouse stromal cells from bone marrow
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: VCAM1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • CyTOF-ready
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation
• Application Notes: Blocking adhesion of lymphocyte to bone marrow stromal cells and Inducing leucocytosis. Extremely low level of LPS (< 0.002EU/ug IgG). This antibody is CyTOF ready.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: A 0.2 um filtered solution in PBS - Azide free
• Preservative: No Preservative
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for VCAM-1/CD106 Antibody (AP-MAB0829)

• CD106 antigen
• CD106
• DKFZp779G2333
• INCAM-100
• L1CAM
• MGC99561
• vascular cell adhesion molecule 1
• vascular cell adhesion protein 1
• V-CAM 1
• VCAM1
• VCAM-1

Background

CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (alpha 4/beta 1 integrin) and LPAM-1 (alpha 4/beta 7 integrin). This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with Mouse stromal cells from bone marrow.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VCAM1