USP20 Antibody - BSA Free

Immunohistochemistry-Paraffin: USP20 Antibody [NBP3-14514] - Immunohistochemistry of formalin-fixed, paraffin-embedded human adrenal medulla after heat-induced antigen retrieval.

• Reactivity: Hu, Mu, Rt, Bt, Bv, Ca, Eq, Ha, Pm, Pm-Or, Pm, Rb
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

USP20 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 18 amino acid peptide from internal region of human USP20.
• Epitope: Internal
• Specificity: Human USP20. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (94%), Rat (94%), Hamster (100%), Canine (100%), Bat (94%), Monkey (100%), Primate (100%), Equine (100%), Bovine (94%), Orangutan (94%), Rabbit (100%). Backed by our 100% Guarantee.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: USP20
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: .

Reactivity Notes

Expected reactivity based on percent sequence identity: Opossum (89%), Turkey, Chicken (83%)

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for USP20 Antibody - BSA Free

• Deubiquitinating enzyme 20
• EC 3.4.19.12
• KIAA1003hVDU2
• LSFR3A
• pVHL-interacting deubiquitinating enzyme 2
• ubiquitin carboxyl-terminal hydrolase 20
• ubiquitin specific peptidase 20
• ubiquitin specific protease 20
• ubiquitin thioesterase 20
• Ubiquitin Thiolesterase 20
• Ubiquitin-specific-processing protease 20
• USP20
• VDU2
• VHL-interacting deubiquitinating enzyme 2

Background

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: USP20