UBASH3B/STS1/Tula-2 Antibody [mFluor Violet 610 SE]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Sheep
Conjugate
mFluor Violet 610 SE

UBASH3B/STS1/Tula-2 Antibody [mFluor Violet 610 SE] Summary

Immunogen
E. coli-derived recombinant human UBASH3B/STS1
Gly48-Phe253
Accession # Q8TF42
Specificity
Detects human and rat UBASH3B/STS1 in Western blots.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
UBASH3B
Purity
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for UBASH3B/STS1/Tula-2 Antibody [mFluor Violet 610 SE]

  • Cbl-interacting Protein p70
  • Cbl-interacting protein Sts-1
  • KIAA1959SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling1, nm23-phosphorylated unknown substrate
  • MGC15437
  • nm23-phosphorylated unknown substrate
  • p70
  • STS1
  • STS1EC 3.1.3.48
  • STS-1ubiquitin-associated and SH3 domain-containing protein B
  • Suppressor of T-cell receptor signaling 1
  • T-cell ubiquitin ligand 2
  • TULA-2
  • Tyrosine-protein phosphatase STS1/TULA2
  • UBASH3B
  • ubiquitin associated and SH3 domain containing B

Background

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol UBASH3B