UBASH3B/STS1/Tula-2 Antibody [HRP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: HRP

UBASH3B/STS1/Tula-2 Antibody [HRP] Summary

• Immunogen: E. coli-derived recombinant human UBASH3B/STS1
  Gly48-Phe253
  Accession # Q8TF42
• Specificity: Detects human and rat UBASH3B/STS1 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: UBASH3B
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Alternate Names for UBASH3B/STS1/Tula-2 Antibody [HRP]

• Cbl-interacting Protein p70
• Cbl-interacting protein Sts-1
• KIAA1959SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling1, nm23-phosphorylated unknown substrate
• MGC15437
• nm23-phosphorylated unknown substrate
• p70
• STS1
• STS1EC 3.1.3.48
• STS-1ubiquitin-associated and SH3 domain-containing protein B
• Suppressor of T-cell receptor signaling 1
• T-cell ubiquitin ligand 2
• TULA-2
• Tyrosine-protein phosphatase STS1/TULA2
• UBASH3B
• ubiquitin associated and SH3 domain containing B

Background

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UBASH3B