UBASH3B/STS1/Tula-2 Products

Description

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Bioinformatics

Entrez	84959 Human
Uniprot	NP_116262 Human NP_116262.2 Human Q8TF42 Human Q96IG9 Human
Product By Gene ID	84959
Alternate Names	Cbl-interacting protein p70 Cbl-interacting protein Sts-1 KIAA1959SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling1, nm23-phosphorylated unknown substrate MGC15437 nm23-phosphorylated unknown substrate P70 p70 STS1EC 3.1.3.48 STS-1ubiquitin-associated and SH3 domain-containing protein B Suppressor of T-cell receptor signaling 1 T-cell ubiquitin ligand 2 TULA-2 Tyrosine-protein phosphatase STS1/TULA2 ubiquitin associated and SH3 domain containing B