UBASH3B/STS1/Tula-2 Products

Antibodies
UBASH3B/STS1/Tula-2 Antibody
UBASH3B/STS1/Tula-2 Antibody
NBP2-34053
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
UBASH3B/STS1/Tula-2 Antibody
UBASH3B/STS1/Tula-2 Antibody
AF6696
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Sheep Polyclonal
UBASH3B/STS1/Tula-2 Antibody
UBASH3B/STS1/Tula-2 Antibody
NBP1-92456
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
UBASH3B/STS1/Tula-2 Overexpre ...
UBASH3B/STS1/Tula-2 Overexpression...
H00084959-T01
Species: Hu
Applications: WB
Proteins
UBASH3B/STS1/Tula-2 Recombina ...
UBASH3B/STS1/Tula-2 Recombinant Pr...
H00084959-P01
Species: Hu
Applications: WB, ELISA, PA
UBASH3B/STS1/Tula-2 Partial R ...
UBASH3B/STS1/Tula-2 Partial Recomb...
H00084959-Q01
Species: Hu
Applications: WB, ELISA, PA
UBASH3B/STS1/Tula-2 Recombina ...
UBASH3B/STS1/Tula-2 Recombinant Pr...
NBP2-34053PEP
Species: Hu
Applications: AC

Description

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 84959
Alternate Names
  • nm23-phosphorylated unknown substrate
  • P70
  • Cbl-interacting protein Sts-1
  • Tyrosine-protein phosphatase STS1/TULA2
  • MGC15437
  • T-cell ubiquitin ligand 2
  • Suppressor of T-cell receptor signaling 1
  • TULA-2
  • Cbl-interacting protein p70
  • STS1EC 3.1.3.48
  • STS-1ubiquitin-associated and SH3 domain-containing protein B
  • KIAA1959SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling1, nm23-phosphorylated unknown substrate
  • p70
  • ubiquitin associated and SH3 domain containing B

Diseases related to UBASH3B/STS1/Tula-2

Discover more about diseases related to UBASH3B/STS1/Tula-2.

Behcet Syndrome
Inflammatory Disorder

Pathways for UBASH3B/STS1/Tula-2

View related products by pathway and learn more about each of the pathways below.

Mast Cell Degranulation
Pigmentation
Pathogenesis

PTMs for UBASH3B/STS1/Tula-2

Learn more about PTMs related to UBASH3B/STS1/Tula-2.

Phosphorylation
Dephosphorylation

Bioinformatics Tool for UBASH3B/STS1/Tula-2

Discover related pathways, diseases and genes to UBASH3B/STS1/Tula-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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