TYRP1 Antibody (TA99 + TYRP1/807)

Product Discontinued

TYRP1 Antibody (TA99 + TYRP1/807) Summary

• Immunogen: SK-MEL-23 cells (TA99); Recombinant full-length human TYRP1 protein (TYRP1/807)
• Localization: Cytoplasmic
• Marker: Melanoma Marker
• Specificity: It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: TYRP1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml
  • Immunocytochemistry/ Immunofluorescence 1-2 ug/ml
  • Immunofluorescence 1 - 2 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml
  • Western Blot 0.5 - 1.0 ug/ml
• Application Notes: Immunohistochemistry (Frozen Only): 1-2ug/ml for 30 minutes at RT.
  Optimal dilution for a specific application should be determined.
• Theoretical MW: 75 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10 mM PBS with 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein A or G purified

Alternate Names for TYRP1 Antibody (TA99 + TYRP1/807)

• b-PROTEIN
• CAS25,6-dihydroxyindole-2-carboxylic acid oxidase
• Catalase B
• CATB
• EC 1.14.18
• EC 1.14.18.-
• EC 1.14.18.1
• Glycoprotein 75
• GP75DHICA oxidase
• Melanoma antigen gp75
• TRP-1
• TRPTYRP
• tyrosinase-related protein 1TRP1
• TYRRP

Background

TYRP1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TYRP1