Tyrosine Hydroxylase Antibody (5C7.2E8) [Alexa Fluor® 488]

Images

 
Flow Cytometry: Tyrosine Hydroxylase Antibody (5C7.2E8) [Alexa Fluor (R) 488] [NBP2-42211AF488] - An intracellular stain was performed on SH-SY5Y cells with Tyrosine Hydroxylase (5C7.2E8) antibody NBP2-42211AF488 (blue) ...read more

Product Details

Summary
Reactivity Hu, Rt, Po, Ca, ChHa, RbSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
Clone
5C7.2E8
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 488

Tyrosine Hydroxylase Antibody (5C7.2E8) [Alexa Fluor® 488] Summary

Immunogen
Partial recombinant human Tyrosine Hydroxylase protein made to a C-terminal sequence (between amino acids 300-528) [UniProt P07101]
Localization
Cytoplasm, Membrane, Nucleus
Marker
Neuronal Marker
Predicted Species
Porcine (92%), Rabbit (90%), Canine (93%), Chinese Hamster (91%). Backed by our 100% Guarantee.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TH
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Immunogen's sequence similarity with other species: Mouse (88%), Rat (88%), Bovine (88%), Chicken (69%), Xenopus (68%), Zebrafish (64%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Tyrosine Hydroxylase Antibody (5C7.2E8) [Alexa Fluor® 488]

  • DYT14
  • DYT5b
  • EC 1.14.16
  • EC 1.14.16.2
  • TH
  • TYH dystonia 14
  • TYH
  • Tyrosine 3-hydroxylase
  • tyrosine 3-monooxygenase
  • Tyrosine Hydroxylase

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Tyrosine Hydroxylase Antibody (NBP2-42211AF488) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP2-42211AF405
Alexa Fluor 647 Labeled NBP2-42211AF647
Alexa Fluor 700 Labeled NBP2-42211AF700
Allophycocyanin Labeled NBP2-42211APC
Biotin Labeled NBP2-42211B
DyLight 350 Labeled NBP2-42211UV
DyLight 405 Labeled NBP2-42211V
DyLight 488 Labeled NBP2-42211G
DyLight 550 Labeled NBP2-42211R
DyLight 650 Labeled NBP2-42211C
DyLight 680 Labeled NBP2-42211FR
DyLight 755 Labeled NBP2-42211IR
HRP Labeled NBP2-42211H
PE Labeled NBP2-42211PE
PerCP Labeled NBP2-42211PCP

Additional Array Products

Bioinformatics Tool for Tyrosine Hydroxylase Antibody (NBP2-42211AF488)

Discover related pathways, diseases and genes to Tyrosine Hydroxylase Antibody (NBP2-42211AF488). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Tyrosine Hydroxylase Antibody (NBP2-42211AF488)

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Pathways for Tyrosine Hydroxylase Antibody (NBP2-42211AF488)

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PTMs for Tyrosine Hydroxylase Antibody (NBP2-42211AF488)

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Research Areas for Tyrosine Hydroxylase Antibody (NBP2-42211AF488)

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Blogs on Tyrosine Hydroxylase.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Tyrosine hydroxylase - a marker for dopaminergic neurons in the central nervous system
Tyrosine hydroxylase is a member of the aromatic amino acid hydroxylase (AAAH) family.  It is expressed throughout the central nervous system (CNS) and catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which can be, thr...  Read full blog post.

Tyrosine Hydroxylase - rate-limiting enzyme in catecholamine synthesis
Catecholamines are tyrosine-derived hormones that are produced in the adrenal gland. They include epinephrine, norepinephrine, and dopamine and are used as neurotransmitters by the central and peripheral nervous system. The rate limiting enzyme in...  Read full blog post.

A Big Guy for the Catecholamine Synthesis - Tyrosine hydroxylase (TH)
In the synthesis pathway for the catecholamines - dopamine, epinephrine, and norepinephrine, tyrosine hydroxylase is the rate-limiting enzyme. Through alternative mRNA splicing, a wide molecular diversity of TH isoforms are generated that are tissue-s...  Read full blog post.

Tyrosine Hydroxylase Deficiencies and Neurodegeneration
Tyrosine hydroxylase is the rate-limiting enzyme in the synthesis pathway of the catecholamines dopamine, epinephrine, and norepinephrine. Alternative mRNA splicing generates a wide molecular diversity of TH isoforms that are tissue specific and produ...  Read full blog post.

Tyrosine Hydroxylase Deficiency and Brain Disorders
 Tyrosine hydroxylase catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. A hallmark of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra. Mutations in cas...  Read full blog post.

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Bioinformatics

Gene Symbol TH
Entrez