Tyrosine Hydroxylase Products

Antibodies
Tyrosine Hydroxylase Antibody ...
Tyrosine Hydroxylase Antibody
Species: Hu, Mu, Rt, Dr, I, Ma
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-FrFl
Host: Rabbit Polyclonal
Tyrosine Hydroxylase Antibody ...
Tyrosine Hydroxylase Antibody
NB300-110
Species: Hu, Mu, Rt, Av, Ma, Rb, Re
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-FrFl
Host: Sheep Polyclonal
Tyrosine Hydroxylase [p Ser40 ...
Tyrosine Hydroxylase [p Ser40] Ant...
NB300-173
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr
Host: Rabbit Polyclonal
Lysates
Tyrosine Hydroxylase Overexpr ...
Tyrosine Hydroxylase Overexpressio...
NBP2-11149
Applications: WB
Proteins
Tyrosine Hydroxylase Full Len ...
Tyrosine Hydroxylase Full Length R...
NBP1-42461
Species: Hu
Applications: IHC-P
Tyrosine Hydroxylase Recombin ...
Tyrosine Hydroxylase Recombinant P...
NBP2-38903PEP
Species: Hu
Applications: AC
Tyrosine Hydroxylase Recombin ...
Tyrosine Hydroxylase Recombinant P...
NBP2-52633
Species: Mu
Applications: PAGE
RNAi
Tyrosine Hydroxylase RNAi
Tyrosine Hydroxylase RNAi
H00007054-R03
Species: Hu
Tyrosine Hydroxylase RNAi
Tyrosine Hydroxylase RNAi
H00007054-R01
Species: Hu
Tyrosine Hydroxylase RNAi
Tyrosine Hydroxylase RNAi
H00007054-R02
Species: Hu

Description

Tyrosine hydroxylase (TH) is a nervous system enzyme that catalyzes the hydroxylation of L-tyrosine to L-DOPA. As L-DOPA is a precursor to many critical neurotransmitters,TH is considered the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. Tyrosine hydroxylase has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and the availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 7054
Alternate Names
  • TYH dystonia 14
  • TH
  • EC 1.14.16.2
  • EC 1.14.16
  • Tyrosine 3-hydroxylase
  • tyrosine 3-monooxygenase
  • DYT5b
  • DYT14
  • tyrosine hydroxylase

Research Areas for Tyrosine Hydroxylase

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Prostate Cancer
Tyrosine Kinases

Bioinformatics Tool for Tyrosine Hydroxylase

Discover related pathways, diseases and genes to Tyrosine Hydroxylase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Tyrosine Hydroxylase Blog Posts

Check out the latest blog posts on Tyrosine Hydroxylase.
The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...    Read more.
Tyrosine hydroxylase - a marker for dopaminergic neurons in the central nervous system
Tyrosine hydroxylase is a member of the aromatic amino acid hydroxylase (AAAH) family.  It is expressed throughout the central nervous system (CNS) and catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which can be, thr...    Read more.
Tyrosine Hydroxylase - rate-limiting enzyme in catecholamine synthesis
Catecholamines are tyrosine-derived hormones that are produced in the adrenal gland. They include epinephrine, norepinephrine, and dopamine and are used as neurotransmitters by the central and peripheral nervous system. The rate limiting enzyme in...    Read more.
A Big Guy for the Catecholamine Synthesis - Tyrosine hydroxylase (TH)
In the synthesis pathway for the catecholamines - dopamine, epinephrine, and norepinephrine, tyrosine hydroxylase is the rate-limiting enzyme. Through alternative mRNA splicing, a wide molecular diversity of TH isoforms are generated that are tissue-s...    Read more.
Tyrosine Hydroxylase Deficiencies and Neurodegeneration
Tyrosine hydroxylase is the rate-limiting enzyme in the synthesis pathway of the catecholamines dopamine, epinephrine, and norepinephrine. Alternative mRNA splicing generates a wide molecular diversity of TH isoforms that are tissue specific and produ...    Read more.
Tyrosine Hydroxylase Deficiency and Brain Disorders
 Tyrosine hydroxylase catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. A hallmark of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra. Mutations in cas...    Read more.
Read more Tyrosine Hydroxylase related blogs.