TWEAK/TNFSF12 Antibody - BSA Free

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] - Staining of human skin shows strong cytoplasmic positivity in squamous epithelial cells.

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -Staining of human rectum shows strong cytoplasmic positivity in glandular cells.

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

TWEAK/TNFSF12 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TWEAK/TNFSF12 Antibody - BSA Free (NBP2-46811) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: QEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFSF12
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  TWEAK/TNFSF12 Recombinant Protein Antigen (NBP2-46811PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (81%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for TWEAK/TNFSF12 Antibody - BSA Free

• APO3 ligand
• APO3LMGC20669
• DR3LGTWEAKAPO3/DR3 ligand
• MGC129581
• TNF-related weak inducer of apoptosis
• TNFSF12
• tumor necrosis factor (ligand) superfamily, member 12
• tumor necrosis factor ligand superfamily member 12
• TWEAK

Background

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia. ITEM-4 antibody reacts with both mouse and human Fn14. It is useful for flow cytometric analysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFSF12
• Entrez:
  • 8742(Human)
• Uniprot:
  • O43508()