TWEAK/TNFSF12 Products

Description

TNF-like weak inducer of apoptosis (TWEAK) is a type II transmembrane TNF superfamily member with strong homology to TNF in its extracellular portion, though less potent in inducing apoptosis. It has been clustered as CD255. TWEAK transcript is expressed broadly in many adult and fetal tissues; however, the staining of human peripheral blood mononuclear cells with TWEAK-specific antibodies shows a more restricted pattern. TWEAK is expressed as membrane-bound and secreted forms. Interaction of TWEAK with its receptors (DR3, Fn14) promotes secretion of IL-8, activation of NF- kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines.

Bioinformatics

Product By Gene ID	8742
Alternate Names	APO3 ligand APO3LMGC20669 DR3LGTWEAKAPO3/DR3 ligand MGC129581 TNF-related weak inducer of apoptosis TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 tumor necrosis factor ligand superfamily member 12 TWEAK

Research Areas for TWEAK/TNFSF12

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
Tumor Suppressors