Western Blot: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 ...read more
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Staining of human liver tissue at 1:100.
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Analysis of methcarn-fixed, paraffin-embedded hippocampus from control (normal) and Alzheimer brain. Quantification in five AD brains and five age-matched ...read more
Hu, Mu, Rt, CanineSpecies Glossary
This product is unpurified. The exact concentration of antibody is not quantifiable.
Principal Names: CGI-135, Fis1, Fis1 homolog, H_NH0132A01.6, tetratricopeptide repeat domain 11, TPR repeat protein 11 ; Claudin 15; CLDN15; TTC11 Official Gene Symbol: TTC11 Gene ID: 51024 (Human) Gene Map Locus: 7q22.1 (Human) Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Keller AC, Knaub LA, McClatchey PM. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxidative Medicine and Cellular Longevity. 2015 Nov 19 (WB, Rat)