TTC11 Antibody


Western Blot: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 more
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Staining of human liver tissue at 1:100.
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Analysis of methcarn-fixed, paraffin-embedded hippocampus from control (normal) and Alzheimer brain. Quantification in five AD brains and five age-matched more

Product Details

Reactivity Hu, Mu, Rt, CanineSpecies Glossary
Applications WB, IHC-P
This product is unpurified. The exact concentration of antibody is not quantifiable.

Order Details

TTC11 Antibody Summary

Amino acids 11-25 of human Fis1 protein were used as the immunogen.
The NCBI accession number for Fis1 is NP_057152. The amino acid sequence used as immunogen is 93% homologous in dog, 73% in mouse and rat, and 66% in chimp (a 512 AA protein).
Predicted Species
Canine (93%). Backed by our 100% Guarantee.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera with PBS and 0.05% BSA
0.05% Sodium Azide


  • Western Blot 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:100
Application Notes
Immunohistochemistry (paraffin): See Wang et al, 2009 for details.
Read Publications using
NB100-56646 in the following applications:

  • 1 publication
  • WB
    10 publications

Reactivity Notes

Reacts with Human and Mouse. Predicted to react with Chimpanzee, Canine.Rat reactivity reported in scientific literature (PMID: 24747740)

Alternate Names for TTC11 Antibody

  • CGI-135
  • FIS1 homolog
  • Fis1
  • fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
  • fission 1 (mitochondrial outer membrane) homolog (yeast)
  • H_NH0132A01.6
  • hFis1
  • mitochondrial fission 1 protein
  • tetratricopeptide repeat domain 11
  • Tetratricopeptide repeat protein 11
  • TTC11TPR repeat protein 11


Principal Names: CGI-135, Fis1, Fis1 homolog, H_NH0132A01.6, tetratricopeptide repeat domain 11, TPR repeat protein 11 ; Claudin 15; CLDN15; TTC11 Official Gene Symbol: TTC11 Gene ID: 51024 (Human) Gene Map Locus: 7q22.1 (Human) Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Fi, Pm
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Ca, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Rt
Applications: WB, ELISA, IHC, IHC-P, S-ELISA
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Po, Ch
Applications: WB, Simple Western, IHC, IHC-P
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu
Applications: WB, Simple Western, ELISA, Flow, IHC, IHC-Fr, IHC-P
Species: Hu, Pm
Applications: WB, Flow, IHC, IHC-P
Species: Hu, Mu, Rt, Po, Ca, Dr, Eq, Ma, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Simple Western, IP
Species: Hu
Applications: WB, ICC/IF, IP, PLA
Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IP
Species: Hu, Mu, Rt, Po, Av, Bv, Fi, Gt, Ma, Re
Applications: WB, ELISA, IHC
Species: Hu, Mu, Rt, Canine
Applications: WB, IHC-P
Supplier Logo

Publications for TTC11 Antibody (NB100-56646)(13)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC-P, WB.

Filter By Application
All Applications
Filter By Species
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using NB100-56646 Applications Species
Placido AI, Pereira CM, Correira SC et al. Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells. Mol. Neurobiol. 2016 Jan 05 [PMID:26732598] (WB, Rat) WB Rat
Santos D, Esteves AR, Silva DF et al. The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease. Mol Neurobiol. 2014 Sep 14 [PMID:25218511] (WB, Human) WB Human
Santos RX, Correia SC, Alves MG et al. Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes. Mol. Cell. Biochem. 2014 May 16 [PMID:24833464] (WB, Rat) WB Rat
Santos RX, Xcorreia SC, Alves MG et al. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic animals. Biochim. Biophys. Acta 2014 Apr 18 [PMID:24747740] (WB, Rat) WB Rat
Liu R, Jin P, Liqunyu et al. Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle. PLoS ONE 2014 Mar 24 [PMID:24658162] (WB, Mouse) WB Mouse
Miller MW, Knaub LA, Olivera-Fragoso LF et al. Nitric oxide regulates vascular adaptive mitochondrial dynamics. Am J Physiol Heart Circ Physiol. 2013 Jun 15 [PMID:23585138]
Wortmann SB, Vaz FM, Gardeitchik T et al. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nat Genet. 2012 Jun 10 [PMID:22683713]
Wang X, Yan MH, Fujioka H et al. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet. 2012 May 1 [PMID:22228096] (WB, Human) WB Human
Xu YF, Gendron TF, Zhang YJ et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci. 2010 Aug 11 [PMID:20702714] (WB) WB
Wang X, Su B, Lee HG et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009 Jul 15 [PMID:19605646] (WB, IHC-P, Human) WB, IHC-P Human
Show All 13 Publications.

Reviews for TTC11 Antibody (NB100-56646) (0)

There are no reviews for TTC11 Antibody (NB100-56646). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for TTC11 Antibody (NB100-56646) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Additional TTC11 Antibody Products

Related Products by Gene

Bioinformatics Tool for TTC11 Antibody (NB100-56646)

Discover related pathways, diseases and genes to TTC11 Antibody (NB100-56646). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TTC11 Antibody (NB100-56646)

Discover more about diseases related to TTC11 Antibody (NB100-56646).

Pathways for TTC11 Antibody (NB100-56646)

View related products by pathway.

PTMs for TTC11 Antibody (NB100-56646)

Learn more about PTMs related to TTC11 Antibody (NB100-56646).

Research Areas for TTC11 Antibody (NB100-56646)

Find related products by research area.

Blogs on TTC11

There are no specific blogs for TTC11, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol FIS1

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB100-56646 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought