TTC11 Antibody

Images

 
Western Blot: TTC11 Antibody [NB100-56646] - Effect of liraglutide on brain cortical mitochondrial fission/fusion markers in female mice with early AD-like pathology. Brain cortical Fis1 (A) protein levels were ...read more
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Analysis of methcarn-fixed, paraffin-embedded hippocampus from control (normal) and Alzheimer brain. Quantification in five AD brains and five age-matched ...read more
Knockdown Validated: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

TTC11 Antibody Summary

Immunogen
Amino acids 11-25 of human Fis1 protein were used as the immunogen.
Predicted Species
Canine (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FIS1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100
  • Knockdown Validated
  • Western Blot 1:500 - 1:1000
Application Notes
Use in Immunocytochemistry/Immunofluorescence reported in scientific literature (PMID:34999205).Immunohistochemistry (paraffin): See Wang et al, 2009 for details. Use in ELISA reported in scientific literature (PMID 27494529)..
Control
NIH 3T3 Whole Cell Lysate
TTC11 Overexpression Lysate
HeLa Whole Cell Lysate
Publications
Read Publications using
NB100-56646 in the following applications:

Reactivity Notes

Predicted to react with Chimpanzee (66%), Canine (93%) .Rat and mouse reactivity reported in scientific literature.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera with PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for TTC11 Antibody

  • CGI-135
  • FIS1 homolog
  • Fis1
  • fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
  • fission 1 (mitochondrial outer membrane) homolog (yeast)
  • H_NH0132A01.6
  • hFis1
  • mitochondrial fission 1 protein
  • tetratricopeptide repeat domain 11
  • Tetratricopeptide repeat protein 11
  • TTC11TPR repeat protein 11

Background

TTC11 is a 17KDa integral membrane protein, and is a novel member of the mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TTC11 Antibody (NB100-56646)(27)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ELISA, ICC/IF, IHC-P, WB.


Filter By Application
ELISA
(1)
ICC/IF
(2)
IHC-P
(1)
WB
(17)
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Filter By Species
Human
(7)
Mouse
(4)
Rat
(4)
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Showing Publications 1 - 10 of 27. Show All 27 Publications.
Publications using NB100-56646 Applications Species
Wang X, Tang Y, Xie N et al. Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling Journal of ethnopharmacology Apr 16 2022 [PMID: 35439546] (WB, Mouse) WB Mouse
Lim S, Deaver JW, Rosa-Caldwell ME et al. Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner American journal of physiology. Endocrinology and metabolism Jan 24 2022 [PMID: 35068192]
Aloysius Dhivya M, Sulochana K, Devi S High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells Cellular Signalling Jan 1 2022 [PMID: 34999205] (ICC/IF, Human) ICC/IF Human
Awasthi S, Hindle A, Sawant NA Et al. RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease Cells Nov 10 2021 [PMID: 34831336]
Lim S, Deaver JW, Rosa-Caldwell ME Et al. Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice Journal of applied physiology (Bethesda, Md. : 1985) Nov 11 2021 [PMID: 34762526]
Ramya R, Bharathidevi SR Paraoxonase 2 protects against the CML mediated mitochondrial dysfunction through modulating JNK pathway in human retinal cells Biochimica et biophysica acta. General subjects Oct 25 2021 [PMID: 34710487] (WB, ICC/IF, Human) WB, ICC/IF Human
Rosa-Caldwell ME, Lim S, Haynie WS Et al. Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice Journal of cachexia, sarcopenia and muscle Sep 29 2021 [PMID: 34585846] (WB, Mouse) WB Mouse
Fernandes T, Resende R, Silva D Et Al. Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer s Disease Biomedicines Jul 24 2021 [PMID: 34440085] (WB) WB
Marques A, Resende R, Silva D et al. Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients Biomedicines May 7 2021 [PMID: 34066918] (WB, Human) WB Human
Brown JL, Rosa-Caldwell ME, Lee DE et al. Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice J Cachexia Sarcopenia Muscle. 2017 Dec 01 [PMID: 28845591] (WB, Mouse) WB Mouse
Show All 27 Publications.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol FIS1
Entrez
Uniprot