Western Blot: TTC11 Antibody [NB100-56646] - Effect of liraglutide on brain cortical mitochondrial fission/fusion markers in female mice with early AD-like pathology. Brain cortical Fis1 (A) protein levels were ...read more
Immunohistochemistry-Paraffin: TTC11 Antibody [NB100-56646] - Analysis of methcarn-fixed, paraffin-embedded hippocampus from control (normal) and Alzheimer brain. Quantification in five AD brains and five age-matched ...read more
Knockdown Validated: TTC11 Antibody [NB100-56646] - Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed ...read more
TTC11 is a 17KDa integral membrane protein, and is a novel member of the mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Beatriz M, VilaCa R, Anjo S et al. Defective mitochondria lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease Journal of Extracellular Biology 2022-10-01 (WB, Human)
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