TSC22/TSC22D1 Antibody (143) [mFluor Violet 450 SE]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 143
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: mFluor Violet 450 SE

TSC22/TSC22D1 Antibody (143) [mFluor Violet 450 SE] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human TSC22/TSC22D1 (Uniprot#: Q15714-2; Met1-Ala144).
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TSC22D1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TSC22/TSC22D1 Antibody (143) [mFluor Violet 450 SE]

• Cerebral protein 2
• Egr5
• KIAA1994
• MGC17597
• Regulatory protein TSC-22
• RP11-269C23.2
• TGFB1I4
• TGFB-stimulated clone 22 homolog
• transforming growth factor beta 1 induced transcript 4
• Transforming growth factor beta-1-induced transcript 4 protein
• transforming growth factor beta-stimulated protein TSC-22
• TSC22 domain family 1
• TSC22 domain family protein 1
• TSC22 domain family, member 1
• TSC22
• TSC22D1
• TSC22DKFZp686O19206

Background

Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TSC22D1