NCOR2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: NCOR2 Antibody [NB120-5802] - Immunofluorescent analysis of NCoR2 (green) showing staining in the nucleus of U251 cells (right) compared to a negative control without primary ...read more
Immunohistochemistry: NCOR2 Antibody [NB120-5802] - Immunohistochemistry analysis of NCoR2 showing positive staining in the nucleus of paraffin-treated Human lung tissue (right) compared with a negative control in the ...read more
Immunocytochemistry/ Immunofluorescence: NCOR2 Antibody [NB120-5802] - Immunofluorescent analysis of NCoR2 (green) showing staining in the nucleus of Neuro-2a cells (right) compared to a negative control without primary ...read more
Immunocytochemistry/ Immunofluorescence: NCOR2 Antibody [NB120-5802] - Immunofluorescent analysis of NCoR2 (green) showing staining in the nucleus of NIH-3T3 cells (right) compared to a negative control without primary ...read more
Immunocytochemistry/ Immunofluorescence: NCOR2 Antibody [NB120-5802] - Immunofluorescent analysis of NCoR2 (green) showing staining in the nucleus of Hela cells (right) compared to a negative control without primary ...read more
Immunohistochemistry-Paraffin: NCOR2 Antibody [NB120-5802] - Immunohistochemistry analysis of NCoR2 showing positive staining in the nucleus of paraffin-treated Mouse brain tissue (right) compared with a negative ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, IP, ChIP, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NCOR2 Antibody Summary

Immunogen
His-tagged fusion protein corresponding to amino acid residues 95-565 from human SMRT.
Localization
Nuclear
Specificity
NB120-5802 detects silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) from human cells.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NCOR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 4 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:100-1:200
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Immunoprecipitation 1:10-1:500
  • Chromatin Immunoprecipitation (ChIP) 1:10-1:500
  • Immunocytochemistry 1:100-1:200
Application Notes
WB: Use at a concentration of 4 ug/ml. Detects a band of approximately 250 kDa (predicted molecular weight: 302 kDa) representing SMRT from HeLa cell nuclear extracts.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Control
HeLa Lysate (NB800-PC9)
NCOR2 Lysate (NBP2-65048)

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NCOR2 Antibody

  • CTG repeat protein 26
  • CTG26
  • CTG26nuclear receptor co-repressor 2
  • FLJ25011
  • NCOR2
  • N-CoR2
  • nuclear receptor corepressor 2
  • retinoic-acid-receptor-associated corepressor
  • silencing mediator for retinoid and thyroid hormone receptors
  • SMAP270
  • SMRT
  • SMRTE
  • SMRTE-tau
  • SMRTT3 receptor-associating factor
  • TNRC14
  • TRAC
  • TRAC1
  • TRAC-1

Background

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid & thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for NCOR2 Antibody (NB120-5802) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Blogs on NCOR2.

Muscular Dystrophy Regulation: Ezh2, NCoR-1
Over the years muscular dystrophies have become a popular area of research. These are a group of inherited disorders that involve an increase in muscle weakness over time. These disorders greatly decrease the quality of life and there are no known cur...  Read full blog post.

NCOR & EZH2 in Muscular Dystrophy
Over the years muscular dystrophies have become a popular area of research. These are a group of inherited disorders that involve an increase in muscle weakness over time. These disorders greatly decrease the quality of life and there are no known cur...  Read full blog post.

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Bioinformatics

Gene Symbol NCOR2
Entrez