Species: Hu, Mu, Rt
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Ca, Bv, Ch, Pm
Applications: WB
Host: Rabbit Polyclonal
Species: Mu, Rt
Applications: WB
Host: Goat Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
8848 |
| Alternate Names |
- Cerebral protein 2
- KIAA1994
- MGC17597
- Regulatory protein TSC-22
- RP11-269C23.2
- TGFB1I4
- TGFB-stimulated clone 22 homolog
- transforming growth factor beta 1 induced transcript 4
- Transforming growth factor beta-1-induced transcript 4 protein
- transforming growth factor beta-stimulated protein TSC-22
- TSC22 domain family 1
- TSC22 domain family protein 1
- TSC22 domain family, member 1
- TSC22DKFZp686O19206
|
Research Areas for TSC22/TSC22D1
Find related products by research area and learn more about each of the different research areas below.
Cancer
