TRPC1 Antibody

Product Discontinued

TRPC1 Antibody Summary

• Immunogen: A synthetic peptide as a part of xenopus TRP-1 (Trpc1, Transient receptor potential protein) conjugated to an immunogenic carrier protein was used as the immunogen.
• Epitope: C-terminal
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TRPC1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot 10-50 ug/ml
• Application Notes: Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 24252728)

Reactivity Notes

Xenopus. Human reactivity reported in scientific literature (PMID: 24252728)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: IgG purified
• Reconstitution Instructions: Please contact technical support for detailed reconstituion instruction.

Notes

Reconstitute in .5 ml of sterile water. Centrifuge to remove any insoluble material.

Alternate Names for TRPC1 Antibody

• HTRP-1
• MGC133334
• MGC133335
• transient receptor potential canonical 1
• transient receptor potential cation channel, subfamily C, member 1
• transient receptor potential channel 1
• Transient receptor protein 1
• TRP1
• TRP-1
• TRP1short transient receptor potential channel 1
• TRPC1

Background

FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. SUBUNIT: Interacts with TRPC3. Interacts with ITPR3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Seems to be ubiquitous.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TRPC1 Antibody (NB100-91315)(2)

Publications using NB100-91315

• NEant I, Leung HC, Webb SE et al. Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians Sci Rep 2019-11-05 [PMID: 31690785] (IF/IHC, Xenopus)
• Arshad A, Chen X, Cong Z et al. TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity. Acta Biochim Biophys Sin (Shanghai). 2013-11-18 [PMID: 24252728] (WB, ICC/IF, Human)

Bioinformatics

• Gene Symbol: TRPC1
• Uniprot:
  • Q9PRI8(Human)