TrkC Antibody

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Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98829] - Rat DRG at 1 : 500 dilution using Rabbit antibody to extracellular domain of TrkC.
Immunohistochemistry-Paraffin: TrkC Antibody [NB100-98829] - IHC on paraffin sections of rat DRG using Rabbit antibody to TrkC.HIER: 1 mM EDTA, pH 8 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um. ...read more
Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98829] - TrkC antibody was tested in neuro2a cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more
Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98829] - IF on rat DRG at 1 : 500 dilution Rabbit antibody to extracellular domain of rat, mouse, human, monkey TrkC (Trk-C, NTRK3, NT-3 growth factor ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 ...read more
Immunohistochemistry-Paraffin: TrkC Antibody [NB100-98829] - IHC on paraffin sections of rat DRG using Rabbit antibody to TrkC. HIER: 1 mM EDTA, pH 8 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um. ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

TrkC Antibody Summary

Immunogen
A synthetic peptide made to the extracellular domain of the human TrkC protein (within residues 50-150). [UniProt Q16288].
Localization
Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NTRK3
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:1000
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
Application Notes
This TrkC antibody is useful for Immunohistochemistry-Paraffin and Immunocytochemistry / Immunofluorescence.In ICC/IF, membrane staining was observed in neuro2a cells. In IHC-P, staining was observed in the membrane of mouse brain and spinal cord. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.05% Sodium Azide
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 0.1 ml sterilized water to desired concentration. Centrifuge to remove any insoluble material.

Alternate Names for TrkC Antibody

  • EC 2.7.10
  • EC 2.7.10.1
  • ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
  • ETV6-NTRK3 fusion
  • gp145(trkC)
  • GP145-TrkC
  • Neurotrophic tyrosine kinase receptor type 3
  • neurotrophic tyrosine kinase, receptor, type 3
  • NT 3 receptor
  • NT-3 growth factor receptor
  • NTRK3
  • TrkC tyrosine kinase
  • TrkC
  • trk-C
  • TRKCneurotrophin 3 receptor
  • tyrosine kinase receptor C

Background

Neurotrophic tyrosine kinase receptor type 3 (NTRK3), commonly known as TRKC, is a member of the protein kinase superfamily, the tyrosine (Tyr) protein kinase family, and more specifically, the insulin receptor subfamily. TRKC is a single pass type I membrane protein that phosphorylates itself (via ligand-mediated auto-phosphorylation) and other proteins in the MAPK pathway upon neurotrophin binding. Mutations to the TRKC gene have been correlated with the development of medulloblastomas, secretory breast carcinomas, and other cancers. TRKC has several transcript variants that encode different isoforms (A= 94.4kDa, B= 68.4kDa, C= 92.8kDa, and D= 93.3kDa), and each isoform has unique signaling properties. Cell differentiation that plays a role in the development of proprioceptive neurons originates via signaling through TRKC. The TRKC protein contains two Ig-like C2-type immunoglobulin-like domains, two leucine-rich repeats (LRR), one leucine rich repeat C-terminal (LRRCT) domain, and one protein kinase domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Blogs on TrkC.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

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Bioinformatics

Gene Symbol NTRK3
Entrez
Uniprot