TrkB [p Tyr816] Blocking Peptide

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Product Details

Summary
Reactivity RtSpecies Glossary
Applications AC
Concentration
LYOPH

Order Details

TrkB [p Tyr816] Blocking Peptide Summary

Description
A peptide to NTRK2.
Immunogen
A synthetic peptide from the region around (and including) phospho Y816 site of rat TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the immunogen.
Modification
p Tyr816
Localization
subcellular location: membrane; single-pass type i membrane protein.
Protein/Peptide Type
Blocking Peptide
Gene
NTRK2

Applications/Dilutions

Application Notes
This peptide is useful as a blocking peptide for NBP1-03499.

For further blocking peptide related protocol, click here.
Positive Control
Oncostatin M/OSM Antibody (H00005008-B01)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
From PBS.
Concentration
LYOPH
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized water.

Notes

After reconstituted, glycerol (1:1) may be added for additional stability.

Alternate Names for TrkB [p Tyr816] Blocking Peptide

  • BDNF/NT-3 growth factors receptor
  • EC 2.7.10
  • EC 2.7.10.1
  • GP145-TrkB
  • Neurotrophic tyrosine kinase receptor type 2
  • neurotrophic tyrosine kinase, receptor, type 2
  • NTRK2
  • TrkB tyrosine kinase
  • TrkB
  • trk-B
  • TRKBBDNF-tropomyosine receptor kinase B
  • tyrosine kinase receptor B

Background

Receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc-gamma-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Positive Control Lysate(s)

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Bioinformatics Tool for TrkB Peptide (NBP1-03499PEP)

Discover related pathways, diseases and genes to TrkB Peptide (NBP1-03499PEP). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for TrkB Peptide (NBP1-03499PEP)

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Blogs on TrkB.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

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Bioinformatics

Gene Symbol NTRK2
Entrez