Trk (pan) Antibody

Immunohistochemistry-Paraffin: Trk (pan) Antibody [NBP3-12168] - Formalin fixed paraffin embedded human Cerebellum stained with Trk (pan) antibody (NBP3-12168)

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Trk (pan) Antibody Summary

• Description: Novus Biologicals Rabbit Trk (pan) Antibody (NBP3-12168) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide-KLH conjugate with human Trk A (777-796aa)
• Localization: Cytoplasm
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NTRK1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: IHC-P: recommended pretreatement of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.

Packaging, Storage & Formulations

• Storage: Store at 4°C.
• Buffer: PBS (pH 7.4), 0.2% BSA, Tween-20
• Preservative: 0.05% Sodium Azide
• Purity: Affinity purified

Alternate Names for Trk (pan) Antibody

• High affinity nerve growth factor receptor;MTC;NTRK1;Nucleoprotein TPR;p140-TrkA;Protein TFG;TRK;TRK1;TRKA;Trk-A;Tyrosine-protein kinase receptor

Background

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in drivernegative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NTRK1