Trk (pan) Antibody

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Immunohistochemistry-Paraffin: Trk (pan) Antibody [NBP3-12168] - Formalin fixed paraffin embedded human Cerebellum stained with Trk (pan) antibody (NBP3-12168)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Trk (pan) Antibody Summary

Immunogen
Peptide-KLH conjugate with human Trk A (777-796aa)
Localization
Cytoplasm
Clonality
Polyclonal
Host
Rabbit
Gene
NTRK1
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
IHC-P: recommended pretreatement of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.

Packaging, Storage & Formulations

Storage
Store at 4°C.
Buffer
PBS (pH 7.4), 0.2% BSA, Tween-20
Preservative
0.05% Sodium Azide
Purity
Affinity purified

Background

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in drivernegative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Array NBP3-12168

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Bioinformatics

Gene Symbol NTRK1