TREM1 Products

Description

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]

Bioinformatics

Entrez	54210 Human
Uniprot	NP_061113.1 Human
Product By Gene ID	54210
Alternate Names	CD354 antigen CD354 TREM1 TREM-1 TREM-1Triggering receptor expressed on monocytes 1 triggering receptor expressed on myeloid cells 1 triggering-receptor TREM1

Research Areas for TREM1

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Signal Transduction

Related TREM1 Blog Posts

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TREM1: An inflammatory signal protein with a potential role in cancer TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays...    Read more.

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