Transglutaminase 2/TGM2 Antibody (CUB7402)

Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody (CUB7402) [NBP2-26458] - Formalin fixed paraffin embedded breast carcinoma stained with Transglutaminase 2/TGM2 antibody (NBP2-26458).

• Reactivity: Hu, Gp
• Applications: IHC
• Clone: CUB7402
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Transglutaminase 2/TGM2 Antibody (CUB7402) Summary

• Immunogen: BALB/C mice were injected with purified guinea pig liver TGase II.
• Localization: Cytoplasmic, cell membrane, extracellular matrix
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TGM2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:75
  • Immunohistochemistry-Paraffin 1:50-1:75
• Application Notes: IHC-P: recommended pretreatment of citrate buffer, pH 6.0. Recommended incubation time of 30 min at RT.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4), 0.2% BSA, Tween-20
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Transglutaminase 2/TGM2 Antibody (CUB7402)

• C polypeptide
• EC 2.3.2.13
• G-ALPHA-h
• protein-glutamine gamma-glutamyltransferase 2
• protein-glutamine-gamma-glutamyltransferase
• TG(C)
• TG2
• TGase C
• TGase H
• TGase-2
• TGase-H
• TGC
• TGCGNAH
• TGM2
• Tissue transglutaminase
• transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
• Transglutaminase 2
• Transglutaminase C
• Transglutaminase H
• transglutaminase-2
• tTG

Background

Principal Names: Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Official Gene Symbol: TGM2 Gene ID: 7052 (Human) Gene Map Locus: 20q12 (Human). Tissue type transglutaminase (TGase II) is historically a member of the transglutaminase family that catalyzes a calcium-dependent acyl transfer reaction between peptide bound glutamine and a suitable primary amine. Transglutaminase has been implicated to play parts in diverse biologic processes such as cell proliferation, deposition and stabilization of the fine structure of the extracellular matrix and in wound repair and fibrosis. TGase II is an effector protein during cell death. The protein is induced by retinoic acid and is the autoantigen implicated in celiac disease. Transcript variants encoding three different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Transglutaminase 2/TGM2 Antibody (NBP2-26458)(1)

Publication using NBP2-26458

• Emerson J, Delgado T, Girardi P, Johnson GV Deletion of transglutaminase 2 from astrocytes significantly improves their ability to promote neurite outgrowth on an inhibitory matrix bioRxiv : the preprint server for biology 2023-02-06 [PMID: 36798305] (IP, Mouse)

Bioinformatics

• Gene Symbol: TGM2