TRAM/TICAM2 Antibody (757712) [DyLight 405]

• Reactivity: Mu
• Applications: ICC/IF
• Clone: 757712
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 405

TRAM/TICAM2 Antibody (757712) [DyLight 405] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: E. coli-derived recombinant mouse TRAM/TICAM2
  Met1-Ala232
  Accession # Q8BJQ4
• Specificity: Detects mouse TRAM/TICAM2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TRAM or rhTRIF is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: TICAM2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product MAB43481. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TRAM/TICAM2 Antibody (757712) [DyLight 405]

• MGC129876
• MGC129877
• Putative NF-kappa-B-activating protein 502
• TICAM2
• TICAM-2TIR domain-containing adapter molecule 2
• TIRAP3
• TIRP
• TIRPcytoplasmic adaptor
• toll/interleukin-1 receptor (TIR) domain-containing adapter protein
• Toll/interleukin-1 receptor domain-containing protein
• toll-like receptor adaptor molecule 2
• Toll-like receptor adaptor protein 3
• TRAM
• TRAMNF-kappa-B-activating protein 502
• Trif
• TRIF-related adapter molecule
• TRIF-related adaptor molecule

Background

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TICAM2