TIRAP Antibody

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Western Blot: TIRAP (TLR2 and TLR4) Antibody [NB100-2823] - Analysis of TIRAP (TLR2 and TLR4) using this antibody at 0.1 ug/ml in K562 cell lysate (35 ug protein in RIPA buffer).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TIRAP Antibody Summary

Immunogen
Peptide with sequence C-QTLLKKPKKRPNSPE corresponding to internal region according to NP_001034750.1, NP_683708.1.
Specificity
This antibody is expected to recognize both reported isoforms (NP_001034750.1 and NP_683708.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TIRAP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 24 kDa band observed in lysates of human myeloid erythroblast call line K562 (calculated MW of 23.9 kDa band according to NP_001034750.1 and 24.8 kDa band according to NP_683708.1).
Positive Control
K-562 Lysate (NB820-59464)
Publications
Read Publication using NB100-2823.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TIRAP Antibody

  • adapter protein wyatt
  • Adaptor protein Wyatt
  • MAL
  • MyD88 adapter-like protein
  • MyD88-2
  • TIR domain-containing adapter protein
  • toll/interleukin-1 receptor domain-containing adapter protein
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • Toll-like receptor adaptor protein
  • wyatt

Background

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TIRAP Antibody (NB100-2823)(1)

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol TIRAP
Entrez
Uniprot