Thyroid Peroxidase Antibody (TPO35) [Biotin]

• Reactivity: Hu
• Applications: ELISA, ELISA
• Clone: TPO35
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin

Thyroid Peroxidase Antibody (TPO35) [Biotin] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with human thyroid peroxidase.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TPO
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Direct ELISA
  • ELISA
  • Sandwich ELISA
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-50813. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Alternate Names for Thyroid Peroxidase Antibody (TPO35) [Biotin]

• EC 1.11.1
• MSA
• TDH2A
• thyroid microsomal antigen
• thyroid peroxidase
• thyroperoxidase
• TPXEC 1.11.1.8

Background

Thyroid Peroxidase encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Thyroid Peroxidase Antibody (NBP1-50813B)(1)

Publication using NBP1-50813B

• Xiang YK, Kolkhir P, Scheffel J et al. Most patients with autoimmune chronic spontaneous urticaria also have autoallergic urticaria, but not vice versa The journal of allergy and clinical immunology. In practice 2023-02-16 [PMID: 36805105] (ELISA, Human)
  
  Details:
  Sample type serum

Bioinformatics

• Gene Symbol: TPO