Human IL-11 Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human IL-11 Quantikine ELISA Kit Summary

Background
The Quantikine Human IL-11 Immunoassay is a 4.5-5.0 hour, solid-phase ELISA designed to measure IL-11 in cell culture supernates, serum, or plasma. It contains Sf 21-expressed recombinant human IL-11 and antibodies raised against recombinant human IL-11. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-11 showed... dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-11.
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Specificity
Natural and recombinant human IL-11
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IL11

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using D1100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-11 Quantikine ELISA Kit

  • Adipogenesis inhibitory factor
  • AGIF
  • AGIFoprelvekin
  • IL11
  • IL-11
  • IL-11Oprelvekin
  • interleukin 11
  • interleukin-11
  • Oprelvekin

Background

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-11 (D1100)(27)

We have publications tested in 2 confirmed species: Human, Mouse.


Filter By Application
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Filter By Species
Human
(26)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 27. Show All 27 Publications.
Publications using D1100 Applications Species
A Gallo, N Cuscino, F Contino, M Bulati, M Pampalone, G Amico, G Zito, C Carcione, C Centi, A Bertani, PG Conaldi, V Miceli Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Priming Strategy to Improve Their Properties International Journal of Molecular Sciences, 2022;23(2):. 2022 [PMID: 35055049] (Human) Human
AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021;0(0):108626. 2021 [PMID: 33705953] (Mouse) Mouse
L Panahipour, A Omerbasic, J Nasirzade, R Gruber TGF-&beta Activity of a Demineralized Bone Matrix International Journal of Molecular Sciences, 2021;22(2):. 2021 [PMID: 33440877] (Human) Human
J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH Nature Communications, 2021;12(1):66. 2021 [PMID: 33397952] (Human) Human
AM Gamage, KS Tan, WOY Chan, J Liu, CW Tan, YK Ong, M Thong, AK Andiappan, DE Anderson, Y Wang, LF Wang Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles PloS Pathogens, 2020;16(12):e1009130. 2020 [PMID: 33284849] (Human) Human
M Tylicka, E Matuszczak, A Hermanowic, W D?bek, M Karpi?ska, J Kami?ska, OM Koper-Lenk BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma Brain sciences, 2020;10(10):. 2020 [PMID: 32987792] (Human) Human
MT Agulló-Ort, Ó Gómez-Mart, S Ponce, L Iglesias, L Ojeda, I Ferrer, I García-Rui, L Paz-Ares, V Pardo-Marq Blood Predictive Biomarkers for Patients With Non-small-cell Lung Cancer Associated With Clinical Response to Nivolumab Clin Lung Cancer, 2019;0(0):. 2019 [PMID: 31562055] (Human) Human
Z Chen, X Chen, R Xie, M Huang, W Dong, J Han, J Zhang, Q Zhou, H Li, J Huang, T Lin DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression Mol. Ther., 2019;27(2):326-341. 2019 [PMID: 30660488] (Human) Human
K Terawaki, Y Kashiwase, M Uzu, M Nonaka, Y Sawada, K Miyano, Y Higami, K Yanagihara, M Yamamoto, Y Uezono Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats Oncotarget, 2018;9(78):34748-34764. 2018 [PMID: 30410674] (Human) Human
L Qian Decreased interleukin-11 levels in the semen of infertile males Cytokine, 2018;108(0):57-59. 2018 [PMID: 29573586] (Human) Human
Show All 27 Publications.

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Bioinformatics

Gene Symbol IL11