Western Blot: TERF21P Antibody [NB100-56321] - Detection of hRap1 in 293 cells: Two microgram of anti-Rap1 (Cat. # this antibody. A protein band with an approximate molecular weight of 50 kDa was detected.
Immunocytochemistry/ Immunofluorescence: TERF2IP Antibody [NB100-56321] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were ...read more
Mouse reactivity reported in scientific literature (PMID: 24797474)
Alternate Names for TERF2IP Antibody
dopamine receptor interacting protein 5
Dopamine receptor-interacting protein 5
RAP1TERF2-interacting telomeric protein 1
Repressor/activator protein 1 homolog
telomeric repeat binding factor 2, interacting protein
telomeric repeat-binding factor 2-interacting protein 1
TRF2-interacting telomeric protein 1
TRF2-interacting telomeric RAP1 protein
Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.