Tec Antibody (663921) [Alexa Fluor® 647]

• Applications: WB, IHC
• Clone: 663921
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Tec Antibody (663921) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Tec
  Met1-Met187
  Accession # P42680
• Specificity: Detects human Tec in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

The tyrosine protein kinase Tec is an approximately 70 kDa member of the protein kinase superfamily, tyrosine protein family, and Tec subfamily.  Human Tec is 631 amino acids (aa) in length.  Amino acid residues 4-111 constitute a Tec pleckstrin homology (PH) domain, and aa 113-149 make up a Btk-type zinc finger.  Residues 179-239 form a Src homology 3 (SH3) domain, and aa 247-345 make up a Src homology 2 (SH2) domain.  The region involving positions 365-620 constitutes the catalytic domain of the protein tyrosine kinases.  Human Tec shares 94% aa sequence identity with mouse Tec.  Human Tec is expressed in hematopoietic cell lines including B-cell, T-cell, and myeloid lineages.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.