TCEB1 Antibody (1076415) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 1076415
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

TCEB1 Antibody (1076415) [Alexa Fluor® 700] Summary

• Immunogen: Spodoptera frugiperda, Sf 21 (baculovirus)-derived human VHL/ELOB/ELOC/CUL2/RBX1 Complex
  Accession # Q15369
• Specificity: Detects hElongin B/Elongin C/VHL/CUL2/RBX1 Complex in Direct ELISA
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TCEB1 Antibody (1076415) [Alexa Fluor® 700]

• ELOC
• elongin 15 kDa subunit
• elongin-C
• RNA polymerase II transcription factor SIII subuni
• RNA polymerase II transcription factor SIII subunit C
• SIII p15
• SIII
• TCEB1
• transcription elongation factor B (SIII), polypept
• transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)
• transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
• transcription elongation factor B polypeptide 1
• transcription elongation factor B subunit 1
• transcription elongation factor B, polypeptide 1

Background

Elongin C is a 12kDa, 112aa general transcription elongation factor.  Elongin C, along with Elongin B, Cul2 and Rbx1 to forms a complex with VHL, and Elongin C is required for the function of VHL.  Mutations in Elongin C are responsible for 0.5% to 5% of clear cell renal cell carcinomas.  Tumorigenic mutations frequently occur in a 35-residume domain of VHL responsible for Elongin C binding.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q15369(Human)