TCEB1 Antibody (1076415) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 1076415
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

TCEB1 Antibody (1076415) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects hElongin B/Elongin C/VHL/CUL2/RBX1 Complex in Direct ELISA
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TCEB1 Antibody (1076415) [Alexa Fluor™ Plus 488]

• ELOC
• elongin 15 kDa subunit
• elongin-C
• RNA polymerase II transcription factor SIII subuni
• RNA polymerase II transcription factor SIII subunit C
• SIII p15
• SIII
• TCEB1
• transcription elongation factor B (SIII), polypept
• transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)
• transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
• transcription elongation factor B polypeptide 1
• transcription elongation factor B subunit 1
• transcription elongation factor B, polypeptide 1

Background

Elongin C is a 12kDa, 112aa general transcription elongation factor.  Elongin C, along with Elongin B, Cul2 and Rbx1 to forms a complex with VHL, and Elongin C is required for the function of VHL.  Mutations in Elongin C are responsible for 0.5% to 5% of clear cell renal cell carcinomas.  Tumorigenic mutations frequently occur in a 35-residume domain of VHL responsible for Elongin C binding.

1. Brugarolas J. Molecular genetics of clear-cell renal cell carcinoma. J Clin Oncol. 2014 Jun 20;32(18):1968-76. doi: 10.1200/JCO.2012.45.2003. Epub 2014 May 12. PMID: 24821879; PMCID: PMC4050206.   
2. Stebbins CE, Kaelin WG Jr, Pavletich NP. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science. 1999 Apr 16;284(5413):455-61. doi: 10.1126/science.284.5413.455. PMID: 10205047.   
3. 3.Hakimi AA, Tickoo SK, Jacobsen A, Sarungbam J, Sfakianos JP, Sato Y, Morikawa T, Kume H, Fukayama M, Homma Y, Chen YB, Sankin A, Mano R, Coleman JA, Russo P, Ogawa S, Sander C, Hsieh JJ, Reuter VE. TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype. Mod Pathol. 2015 Jun;28(6):845-853. doi: 10.1038/modpathol.2015.6. Epub 2015 Feb 13. PMID: 25676555; PMCID: PMC4449825.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.